Pathfinder 2e - The Alchemist Handbook
Last Updated: September 22nd, 2020
I will use the color coding scheme which has become common among Pathfinder build handbooks.
- : Bad, useless options, or options which are extremely situational.
- : OK options, or useful options that only apply in rare circumstances
- : Good options.
- : Fantastic options, often essential to the function of your character.
The Alchemist is an interesting class, serving their party as a Healer, Scout and Striker, and potentially as a Defender or Blaster depending on their Field of Research. The Alchemist's role in the party most closely resembles a Rogue.
In many ways, the Alchemist functions like a Wizard whose spell list is instead a list of items. The Formula Book works much like a spellbook: different levels of each formula must be learned like different levels of the same spell, and you can learn extra formulas from other Alchemists or from their Formula Books.
The way your alchemist employs their suite of alchemical tools dependes heavily on your choice of Research Field: The Bomber emphasizes throwing really cool bombs with a dizzying array of exciting and useful options, the Mutagenist emphasizes using mutagens to make yourself a mutaded monster in combat (but is mechanically an unusable trainwreck), and the Chirurgeon resembles an alchemical medicine vending machine that's empty except for off-brand tonic water.
Alchemist Class Features
Key Ability: Intelligence.
: 8+Con per level. Better than a wizard, but don't go into melee without padding your AC and your hit points.
: The Alchemist's only really good proficiency is in skills, though notably they get proficiency with Alchemical Bombs, and unarmed strikes, which are the Alchemist's best weapon options in most cases.
- : Only Trained, no dependence on Wisdom, and your proficiency doesn't increase until 11th level, making you one of the worst in the game at Perception.
- : Two good saves, and in light armor you'll want high Dexterity.
- : Only one fixed skill, but 3+int gets you more total starting skills than many other classes.
- : Only Trained in simple and alchemical weapons and unarmed attacks. Simple and Alchemical Bombs goes up to Expert, but no higher than that.
- : Only unarmored defense and light armor, and your proficiency only improves at levels 13 amd 19. Very few classes get worse armor than the Alchemist.
- Class DC: The Alchemist's class DC only matters for a few Alchemist class feats, but you want as much Intelligence as possible to get extra Infused Reagents so your class DC is going to be fantastic anyway.
: The Alchemist's defining class feature.
- : Like spell slots for a spellcaster, these are the limiting factor on your most powerful options, and you can only exceed this capability by spending money on items (more alchemical items in your case, or scrolls/wands/etc. for a spellcaster). You get a lot, and at 5th level your Field Discovery will allow you to create some items for free using Quick Alchemy depending on your Research Field, but these are an essential way to create high-level alchemical items without bankrupting yourself. There aren't many ways to get more Infused Reagents per day (a familiar can produce one batch per day), but you may find those options worthwhile, especially at low levels where you have few to spend.
- : This is your go-to usage for your Infused Reagents. You get two items per batch, and even though they need to be the same item (with some exceptions, depending on your Research Field), that's a better deal than you get from Quick Alchemy. Prepare any staple items you know you'll need (bombs, elixirs of life, mutagens, etc.) at the beginning of the day, but leave a few batches for Quick Alchemy when you need something unusual on short notice.
- : Until 5th level this is a backup option for when you didn't think to prepare some specific alchemical item that you need in a specific situation. Once you get Perpetual Infusions, you can use this to create a small number of items for free depending on your Research Field. These free items are a bottomless supply, and depending on your Research Field they may be important enough that you use them every turn.
: This works much like the Wizard's spellbook: You learn a few formulae at first level, then two more at each level, but you can also copy new formulae from other sources, such as other Alchemists' formula books. Like the Wizard, you must learn new version of the formula for each version of a specific alchemical item, so if you want Alchemist's Fire to be a fixture of your toolkit, you'll need to learn each of the four versions as you gain levels.
Research Field: See "Subclasses - Research Field", below.
Alchemist Feats: See Alchemist Feats, below.
Skill Feats: Standard for everyone except the Rogue.
General Feats: Standard.
Skill Feats: Standard for everyone except the Rogue.
Ability Boosts: Standard.
Ancestry Feats: Standard.
: This presents a significant jump in power for the Alchemist. The ability to create some alchemical items for free every turn allows you to use your signature class feature essentially without limit. The effectiveness of this feature varies by Research Field, but regardless of Research Field this is a central part of how you play your character.
: This is as good as you will ever get at weapons, including alchemical bombs. Improving your profieciency is great, of course, but never getting past Expert means that at high levels you may have trouble hitting with attacks.
: Will saves are your worst save, so any bonus is welcome.
: A bottomless supply of some of the most important items in your arsenal. You may still want to spend some of your Infused Reagents on higher-level items and on items which you can't craft for free with Perpetual Infusion, but you may want to save those for when they're really important.
: Always helpful, but the Alchemist Class DC is used for very few things.
: Always welcome, but you never get better than Expert.
: Situational. Generally when you need to create an item in a hurry you only need one, and if you need more than one it's one of the items you can create for free with Perpetual Infusions. It's totally unclear how this interacts with Perpetual Infusions, so I can't tell if you can use this to create two items for free.
: Better saves are always great.
: A significant improvement to the items that you can create with Perpetual Infusions. Going from lesser to moderate often doubles the numerical effects of the item.
: Depending on your Research Field, this is the feature that definitively sets you apart from other Research Fields.
: More AC is always great, but you get this very late, which is a problem for Mutagenists.
: Weapon Specialization is great, but the Alchemist never gets past Expert so you'll never see the +3/+4 damage bonuses. Alchemical bombs are listed as Martial Weapons, so they're weapons and you get the damage bonus just like you would with other weapons..
: Unless you took Enduring Alchemy this is probably useless.
: Better saves are always great, and since many Reflex saves are "basic saving throws" a Critical Success is a significant improvement. It's the difference between half damage and no damage at all.
: Always helpful, but the Alchemist Class DC is used for very few things.
: Roughly a 50% numeric improvement to your favorite alchemical items.
: More AC is always great, but you get this very late, which is a problem for Mutagenists.
Subclasses - Research Field
Alchemists are the only class trained in alchemical bombs, and if you're not a Bomber you're not using them to their full potential. The biggest drawback to bombs is their disposable nature, which means that they become expensive quickly, and the Bomber gets to make bombs for free using Quick Alchemy. That immediately means that you don't need weapon options beyond bombs (except for extremely long range), allowing you to focus all of your class feats on making your bombs terrifying.
- : You're going to use a lot of bombs most days, so getting some extra for free is a great way to save money on crafting.
- : Lesser bombs are your bread and butter. You need to be able to churn these things out as fast as possible. However, you only get to pick two types of bombs which you can do this with, so pick two which you'll use a lot. I recommend fire for straight damage and something with a good debuff.
- : A significant increase in your damage output at no cost. At this level you can start crafting Greater bombs, but they're extremely expensive. If you don't need the extra damage, your free option is now massively more dangerous.
- : Somewhat underhwleming by this level, but more splash area means more splash damage. And if you're raining cheap bombs over an area with Calculated Splash and Expanded Splash, you're dealing at least 5 splash damage to everything in a 15-foot radius burst even if you miss. Do that three times a round with lesser bombs (laughably inexpensive at this level), and you're doing a sizeable amount of damage at no effort, plus possibly applying effects like clouds of smoke, speed penalties, etc.
- : Even more damage and bigger debuffs!
Chirurgeon is great conceptually, but it simply doesn't offer enough to make it worthwhile. The Medicine skill and a handful of cheap alchemical items will do the job just as well, and being able to squander your Infused Reagents on a few extra antiplagues and antitoxins doesn't make you any better at healing than any character with ranks in Medicine who simply purchased antiplagues/antitoxins for the relatively rare circumstances where they're useful. At least you're not a Mutagenist, though.
- : Getting 50% more items out of your Infused Reagents is pretty great, and elixirs are a good option because they include useful options like Elixir of Life and mutagens.
- : Lesser Antiplague/Antitoxin cost 3gp each and they're extremely situational.
- : Antiplague/Antitoxing are still extremely situational, and increasing their bonus doesn't fix that.
- : At this level you can craft a Greater Elixir of Life and heal a guaranteed 92 hit points. In a pinch that's really good, but in-combat healing should be a rare fallback for when things are going badly.
- : Amazingly, making better versions of an item you only infrequently need still doesn't make them especially useful.
Mutagenists are conceptually cool: Drink some stuff, and mutate yourself to adjust your capabilities. While each individual ability granted to the Mutagenist is fine (with some exceptions), the Mutagenist is absolutely riddled with design issues. Bestial mutagen, your go-to combat option, is redundant with weapon runes which you'll still need to remain relevant in combat. Several of the Research Field's features are inoperable for several levels until a later feature comes online, and many of the Mutagenists's signature features are redundant with or worse than options provided by Alchemist Class Feats.
For comparison, The Mutagenist benefits much less from the ability to create mutagens for free than a Bomber does from their free items, and you're not significantly better at actually using mutagens than any random person until you get Greater Field Discovery at 13th level so that you can combine two at once.
The way mutages are designed further hampers you: the only mutagens that are universally useful in combat (Bestial and Juggernaut) aren't very good unless you invest class feats to improve them, so you're locked into several feats if you want to meat a bare minimum amount of effectiveness.
The mutagenists only redeeming mechanical quality is that you can use Perpetual Infusion and Revivifying Mutagen to get infinite healing, but in a game where there are Focus Spells that restore hit points that's not unique.
If you're working from the printed Core Rulebook, note that the Mutagenist entry under Research Field got errata to replace the last paragraph with Mutagenic Flashback. Mutagenic Flashback allows you to reactivate the effects of a previously-used Mutagen for 1 minute as a Free Action. In many ways that's a free Mutagen, but the Action savings is likely more significant.
- : Mutagens are a subset of elixirs, so you can't craft as many options while still getting 50% more per batch of Infused Reagents, as a Chirurgeon could,but you get the unique option of crafting any three mutagens rather than 2 or 3 of the same item. Be sure to bring a few different types so that you're ready for anything.
- : Combined with Revivifying Mutagen, this means that you can repeatedly create a free mutagen, consume it, then end it to heal. Pick you favorite go-to mutagen (probably Bestial or Juggernaut), and make sure that you always have it running unless you're actively healing yourself.
- : Linear improvement to your favorite mutagens.
- : Combine Bestial and Juggernaut and wade into melee like a horrifying mutated wrecking ball. This is why you play a Mutagenist for mutagen builds rather than any other option. You can do this with Combine Elixirs, but it's not quite as effective.
- : Another linear increase in effectiveness.
Poisons in Pathfinder are extremely effective, but they're also complicated and like many offensive items they're limited by cost, a fixed save DC, and the action economy around using them. The Toxologist addresses all of those issues. Any alchemist can make alchemical poisons for free using their Infused Reagents, and Field Discovery allows you to create even more. The Research Field allows you to apply poisons in one Action instead of the usual 2, though you still need to spend one Action to draw the poison unless you create it with Quick Alchemy. The Research Field feature also sets the save DC for your poisons to your Class DC, allowing you to rely on lower-level poisons well past their normal usable level range.
One very important thing to remember about the Toxologist is that your best asset is your allies. Every weapon in your party is a vehicle to deliver injury poisons, and you are at your most effective when you're delivering as many poisons as possible as quickly as possible. To achieve that goal, you need to share your poisons with your party and trust that they'll end up in the right place. Choosing an array of go-to poisons to apply to your party's weapons is a great investment of real-world time, and going into every encounter with your allies' weapons poisoned will tilt many encounters in your party's favor.
Despite all the benefits of poisons, be aware of its limitations. Many enemies are immune to poison (constructs, undead, etc.), so you'll need other options to handle those foes like bombs or conventional weapons. Poison can also be difficult to apply in combat, and if you're using a weapon that needs to be loaded like a crossbow you may have turns where you don't do anything except get ready to do something on your next turn. Managing your actions will be especially challenging in combat, so going into combat with poisons ready to go is essential. You need to have a big impact early in combat in case you find yourself struggling as commbat drags on.
- : Increasing the save DC of poisons makes low-level poisons viable at much higher level, opening up a much broader array of poison options than just whatever is highest-level. Reducing the Action cost from 2 to 1 also means that you can more easily apply poisons in combat, allowing you to quickly employ the right poison for the situation.
- : Much like bombs, poisons are a single-use item that you'll burn through quickly in combat. Getting 50% more for free each day will stretch your limited resources considerably, allowing you to more easily rely on your best options.
- : Quick Alchemy is hard to use with poison because you need to create it as an Action, apply it to your weapon as an Action, and then ideally hit something with it using your remaining Action. If you're going to go through the difficult to do that, it would be nice if it was with an item better than a 1st-level poison. Be sure to pick poisons which you can deliver quickly (contact or injury poisons typically) so that you can appy them before the duration expires. Your best bet may be to share the effect with allies and/or to get a familiar which can help. Giving your familiar Independent, Lab Assistant, and Independent allows it to use Quick Alchemy every turn without cutting into your Actions, provided that your DM decides that your familiar is inclined to do so without being commanded.
- : Increasing the level of the poisons is great, but it doesn't solve the action economy problems.
- : The ability to combine two poisons is spectacular, but since this can't be used on ammunition you need to put this on a melee weapon. Melee is a hard place for the Toxologist due to the action economy challenges of using poisons, but you can use this outside of combat to set your party up with poisons that will give your party an advantage early in combat.
- : Again: better poisons are great, but they don't solve the Action Economy problem.
Most alchemists are defined by their Intelligence, but they require Dexterity to be successful at their attacks with alchemical bombs, and they require Constitution and Wisdom to compensate for poor Perception and generally poor durability. Expect to invest your 4 ability boosts at every fifth level in those four abilities.
: Alchemical items are Light bulk, so you can carry a ton of them. You're also very good at crafting, so crafting a bag of holding is a great option. However, you may want 10 so that you can wear leather armor without worrying about the check penalty.
: Dexterity will improve your poor AC and make you more accurate with alchemical bombs and ranged weapons.
: Your AC is bad. If you have less than 14, expect to die.
: Sets your ability DC and improves your crafting.
: You need some to boost your poor Will saves and your poor Perception, but it's the least important of the ability scores that you care about.
: Dump. Nothing about the Alchemist involves Charisma.
Mutagenists work a bit differently from other alchemists. Mutagens offer numerous great ways to improve your durability and to add melee options like claws and bite attacks. However, this means that you need to more heavily invest in Strength and Constitution or in weapons to be a meaningful threat in melee.
: You need it for damage output when you move into melee with Feral Mutagen.
: You need it for your terrible AC.
: You need it for when your terrible AC fails to protect you.
: You need it to craft mutagens.
: You need it for your terrible Will saves and your terrible Perception.
: Dump. You're already MAD enough as it is.
Bonuses to important abilities like Constitution and Intelligence are great, but we can also benefit from other racial options like better weapon proficiencies, and energy damage resistances (especially fire) to mitigate potential splash damage.
: The Ability Boosts work fine, but none of the Catfolk's feats add anything meaningful to the Alchemist.
: Constitution, Wisdom, the Free increase goes into Intelligence, and Dwarfs get more starting hit points than other published races. Forge Dwarf gets you fire resistance, and Strong-blooded gets you poison resistance in case you're exposed to your own handiwork. Unfortunately, none of the ancestry feats are especially interesting for the Alchemist.
: Dexterity, Intelligence, and the Free increase goes into Constitution. Arctic, Cavern, and Seer elf are all good options. Elven Weapon Familiarity gets you access to several excellent weapon options like rapiers and bows. However, elves have low ancestry hit points so be cautious at low levels.
: An increase to Charisma doesn't help us, so use the Voluntary Flaws rule to get a second Free increase, and to turn the Charisma increase into a net -2. Then you get +2 Dex, +2 Con, +2 Int, and -2 Cha. Sensate Gnome and Umbral Gnome are both great choices. You may also consider Fey-Touched or Wellspring, but innate spells are Charisma-based and we're dumping Charisma, so either rework the ability score spread I suggested or pick a utility cantrip. Animal Accomplice is a great way to get a familiar without spending a class feat, (though its modifiers will be Charisma-based, which isn't great for the Alchemist) and Gnome Weapon Familiarity gets you access to kukris which may be more appealing than daggers.
: An increase to Charisma doesn't help us, so use the Voluntary Flaws rule to get a second Free increase, and to turn the Charisma increase into a net -2. Then you get +2 Dex, +2 Con, +2 Int, and -2 Cha. Charhide Goblin offers fire resistance, and Razortooth Goblin offers a bite attack which can fill in for feral mutagen until your mutagens become more powerful. Snow Goblin and Unbreakable Goblin are both great, too, but they don't play to the Alchemist's strengths quite as well. The Burn It! feat is a must-have for goblin alchemists, and Junk Tinker can help to reduce the cost of single-use alchemical items which you might choose to craft permanently rather than spending your daily Infused Reagents to craft them.
: Dexterity, Wisdom, and the Free increase goes into Intelligence. Unfortunately, none of the heritage options are especially appealing, but I'm partial to Hillock Halfling and Twilight Halfling. Halflings have several excellent ancestry feat options, including universally good options like Halfling Luck. Halfling Weapon Familiarity gets you access to the Filcher's Fork, which is similar to a dagger with Backstabberm, Deadly 1d6, and double throwing range. At 5th level you can take Cultural Adaptability, allowing you to take great ancestry feats from other Ancestries like Animal Accomplice from the Gnome or Burn It! from the Goblin. Normally this takes two feats, so it's a really great option.
: The two Free increases go into Dexterity and Intelligence. If you want more increases, use the Voluntary Flaws rule to get +2 Constitution, -2 Strength, and -2 Charisma. The Half-Elf and Half-Orc heritages don't offer anything that's especially useful for the Alchemist, but Skilled Heritage and Versatile Heritage are fantastic on any character, and humans get several truly excellent ancestry feats. Natural Ambition is always a great idea, Unconventional Weaponry opens up nearly any weapon in the game, Multitalented lets you explore another class with very little commitment, and if you can't decide you can take General Training to get another general feat.
: The Ability Boosts work similarly to the Goblin's (especially if you use the Optional Flaw rules to dump Charisma), but the Kobold's feats don't directly complement the Alchemist quite as well.
: Strength is a hard choice for the Alchemist, so I recommend using the Optional Flaw rules to dump Strength and boost either Dexterity and Intelligence or Constitution and Intelligence. Even then, the only appealing combination I see here is the Mutagenist. The Orc has several feats which will help you thrive in melee, which may be enough to make the Mutagenist a serious melee threat.
: The Ability Boosts work perfectly, and Rat Familiar is a great way to get a familiar if you don't mind it being Charisma-based. However, the Ratfolk's other Ancestry Feat options don't offer much else that's especially helpful. The Cheek Pouches and Pack Rat feat chains are fun and might help a little bit with item management, but they're more about stowing things than retrieving them, and retrieving them is where the Alchemist really needs the help.
: The Ability Boosts are fine, but the Tengu offers nothing else that directly complements the Alchemist.
Look for backgrounds that offer boosts to Intelligence. If you're building a mutagenist you also want a boost to a physical ability score, but other alchemists probably want Dexterity. For skills, see the Skills section, below. The Specialty Crafter feat is great because the Alchemist depends so heavily on crafting, but it's only +1 bonus (+2 at high levels) so you'll be fine without it.
If you're having trouble deciding, here are some suggestions:
Skills and Skill Feats
You get Skill Increases at 3rd and 5th level to raise skills to Expert, increases at 7th, 9th, 11th, and 13th level to raise skills to Master, and increases at 15th, 17th, and 19th level to raise skills to Legendary. That means that you can maximize at most three skills, and the rest of your skills might not advance beyond Trained.
You get Skill Feats at even-numbered levels, giving you a total of 10 Skill Feats (and maybe another from your Background) by 20th level. Generally you want to invest these feats in the same skills which you are choosing to maximize, though in some cases you may want to grab feats from skills which don't require that you be more than Trained.
- (Dex): Too situational, and less useful since you don't have a built-in way to fly.
- (Int): Your ability scores work, but you can't cast Detect Magic and you can't use spellbooks. You can squeeze some more out of Arcana with Arcane Sense, which allows you to cast Detect Magic.
- (Str): A possibility for Mutagenists, but otherwise skip it.
(Int): You get it for free, and since the Alchemist depends so heavily on crafting alchemical items you're going to use it a lot. Increase your proficiency at every possible opportunity.
- Practical Guide to Assurance for more information. : Reliably craft items during downtime, and since alchemists rely heavily on alchemical items you can expect to do this to produce single-use alchemical items like antiplagues and antitoxins which you won't need to use frequently or in large quantities, but which you still want on-hand when they're useful. Scoring a Critical Success isn't a big improvement when crafting items; being able to score a reliable Success is considerably more important. Plus, you can pick up Impeccable Crafting to always get a Critical Success without rolling. See my
: +1 or +2 on all of your Crafting checks to make alchemical items is great when you're crafting alchemical items frequently.
- : Combined with Assurance you may be able to guarantee a Critical Success when crafting.
- (Cha): Charisma is your dump stat.
- (Cha): Charisma is your dump stat.
- (Cha): Charisma is your dump stat.
- (Int): With high Intelligence and lots of trained skills, Lore is a great option for the Alchemist.
- (Wis): Medicine is really good, especially with a couple skill feats like Continual Recovery and Ward Medic. In fact, Medicine is so good that it makes the Chirurgeon weak by comparison.
- (Wis): Your Wisdom might be high enough to make this work, but it doesn't offer anything specific to the alchemist. You might consider the Bonded Animal feat, but aside from a pack animal to carry your alchemical stuff I don't know what you would do with it.
- (Int): Intelligence-based, and you can use it to identify occult magic and "supernatural creatures".
- (Cha): You dumped Charisma.
- (Wis): Similarly useful to Arcana and Occultism, but your ability scores don't work quite as well for it.
- (Int): Knowledge of humanoid societies is crucial in many campaigns, and your Intelligence makes this an easy option.
- (Dex): Most alchemists need Dexterity to make their attacks work, so you're naturally good at Stealth.
- (Wis): Only rarely useful, but you probably have enough Wisdom to make it useful.
- (Dex): Like Stealth, you have the Dexterity to make it work, and Thievery provides the crucial capacities to disable traps and open locks.
For the full list of Alchemist Class Feats, see the Alchemist Feats page on Archives of Nethys.
- : Familiars are really good for a lot of reasons.
- : Extremely situational.
- : Essential for Bombers, but other alchemists might prefer to rely on weapons when range becomes a problem.
- : Absolutely crucial if you intend to us bombs as a frequent part of your combat options.
- : A blowgun deals 1 damage, so if the target has any resistance to piercing damage it's immune to your attack. This makes blowguns a reliably delivery mechanism for injury poisons without the need to invest in expect Runes of Striking. This can be very helpful for the Toxicist, but other alchemists typically won't use poisons enough to make this meaningful.
- : Reducing your Bomb's damage to creatures to just their splash damage is often a huge waste of your limited resources, and spending a minute to strap your bombs to a wall or whatever else does little to improve their effectiveness. The one redeeming quality is that you can use up to 4 bombs and combine their damage for the purposes of resistances, so difficult objects to break like metal doors are less of a problem.
- : Damage resistance to a common damage type is fantastic.
- : For the Mutagenist or the Chirurgeon, this turns into infinite free healing. For everyone else this is an expensive way to turn a mutagen into a healing potion.
- : A great way for the Bomber to control the battlefield, but try not to abuse it too much or your'll find whole rooms choked by smoke to the point that you and your allies can't see your enemies.
- : A must-have for the Bomber. Even Major bombs max out at 4 splash damage normally.
- : If your campaign features strictly limited donwtime and you spend a lot of time crafting extra alchemical items, this might be worth it. But this won't help you much when you walk into a fight.
- : Normally if you're using Quick Alchemy you're planning to use the item immediately, but if you find that you often end a turn with an extra action and nothing good to do with it (which should literally never happen), this is an option. You may also like this for poisons created using Quick Alchemy since it may be difficult to craft the poison and hit the target in the space of a single turn.
- : A fantastic option for Chirurgeons. This means that you no longer need to chase allies around in combat; you can throw things at them instead. There's some question about what the word "willing" means for unconscious characters, but if your GM doesn't consider your ally willing while they're unconscious you should be able to hit their unconscious body without too much effort.
- : Poisons rely on delaing their effects over time, so increasing their duration can make them much more effective. However, the poisons most impacted by this are injury poisons which you'll typically use in combat. Injury poisons typically have a 1-round duration for Stage 1 and a 6-round maximum duration, so you're only extending the duration to 7 rounds. Still, every poison's final stage is its most lethal, so if you can keep enemies at that stage one round longer you'll get a lot out of the effect.
- : Too situational. If you have an ally in need of healing, a single Elixir of Life will suffice. You can also use this to combine mutagens, but the Mutagenist can do this with Greater Field Discovery starting at 13th level, so they should retrain this feat at that points. Other Alchemists might enjoy this if they want to dabble in mutagens, especially once you can get Persistent Mutagen to turn four Infused Reagents into two all-day mutagens.
- : Not essential, even for the Toxologist, but if you're using poisons heavily and fighting in melee this can solve a significant problem. You also get a 1 in 5 chance to retain your poison after a successful Strike so you may be able to deliver it a second time.
- : A must-have for the Bomber. Dazzled applies a 1 in 4 chance of a creature missing any single attack, Flat-footed is great if you're planning additional attacks or if you have a Rogue in the party. You can also apply a speed penalty, but if you want that you should just use a Tanglefoot Bomb. Deafened is mildly annoying, but after combat starts it's not significant enough to justify.
- : In most cases where a cone would be a solution you can just throw the bomb at a creature or space behind or adjacent to your target to avoid hitting an ally.
- : Bestial Mutagen's attacks aren't great on their own, so adding a little extra damage and Deadly (d10) does a lot to improve them. However, adding an extra -1 to AC feels like an unnecessary attempt to balance an attack which is now very slightly better than a nonmagic weapon.
- : Your choice of Research Field will often pigeon-hole you into using one variety of items. This allows you to diversify your capabilities significantly. As an example of a good use case: Most non-bomber alchemists can choose to add bombs to their Quick Alchemy options for an easy combat option.
- : Alchemists are perfectly capable of being sneaky, so you could easily deliver a poisoned attack in the first round of combat before your enemies can respond. There are also numerous ways to make enemies Flat-Footed, including flanking or using certain poisons. A -2 penalty is mathematically significant, and with a little planning this is easy to rely upon. This is essential for the Toxicist.
- : Essential for poisons. Granted, you can do just fine going your whole life without using poison, but it's nice to have the option.
- : Calculated Splash means that your splash damage at least equals your Intelligence, so a Bomber is probably adding +4 or more to the continuous damage from any bomb that they throw..
- : Quicksilver mutagen is really situational, and since it costs a big pile of hit points to use it can't be a go-to option without some serious shenanigans.
- : Instead of replacing your bombs' splash damage, you now add your Intelligence modifier to the existing splash damage. That's at most 4 extra damage, but the real draw here is doubling the splash radius.
- : As far as i can tell none of these debuffs stack with themself. I think Debilitating Bomb is better.
- : Very situational.
- : Powerful Alchemy is better unless you're crafting a bunch of poisons beyond what you can do with Quick Alchemy.
- : It's too expensive to stabilize the concoction, and the consequences for failure are intimidating unless you have a bottomless supply of healing and an adequate time to repeatedly harm and then heal yourself.
- : Generally this means mutagens. Mutagens, and by this level they have hour-long durations and you can craft a small horde of them using Advanced Alchemy during your daily preparations.
- : Absolutely essential for Mutagenists, but worthwhile for any alchemist.
- : Your bomb range now matches that of a shortbow, and you can use Smoke Bomb without inhibiting your own attacks.
- : This is hard to rely upon because the situation in which it works is so specific. It's great if you can make this work, but you'll need to deliberately target creatures with other adjacent creatures in order to have a chance of this applying.
- : You dumped Charisma, and until this point there has been no reason for you to try playing a Face. Your best use for a Silvertongue Mutagen is to give it to someone else.
- : Finally a good feat for elixirs! Of course, you had to take Merciful Elixir to get here, but if your party doesn't have access to spellcasting that can remove things like Blinded you may need this,
- : For some reason you lose Clumsy as an option. Doubling the penalties from Greater Debilitating Bomb is nice, but still not as effective as the flat 1 in 4 chance of failure from being Dazzled or Deafened.
- : Combine this with Invincible Mutagen and you have permanent resistance to physical damage. Even if you're not using mutagens for anything else, this is a really good feat. However, it doesn't get you past the limitation of one mutagen at a time unless you use something like Combine Elixirs.
- : Typically you can address resistances by changing types of bombs, but it's nice to be able to stick to your favorites, especially if you can create them for free with Quick Alchemy.
- : Better than Glib Mutagen by a lot, nad you get telepathy.
- : Eternal elixir has a longer duration, no usage limitation, and affects all elixirs rather than just mutagens. The only use case I can think of is for a Mutagenist because they can have two mutagens running at the same time.
- : This includes fantastic options like Invisibility Potion nand Potion of Flying.
- : Too situational.
- : Carry a few True Elixirs of Life just to use with this feat.
- : Effectively increases the DC to resist Debilitating Bomb by 10, but Debilitating Bomb's effects only last one round so this may not be worth a feat.
- : Conceptually the coolest option, but mechanically not all that interesting. It does allow you to bring recently dead creatures back to life, but at this level you can use rituals or hire NPC spellcasters to do that. It does't give you the option to extend your natural lifespan, which I find terribly disappointing.
- : Because the bomb needs to be Infused, you need to use Quick Alchemy to create the base bomb, then Mega Bomb to upgrade it to a Mega Bomb, then your third action to Interact and throw the bomb. This is only a go-to option if there are multiple enemies in the target area, but if you can hit 2 or more enemies this will be more effective than throwing multiple bombs. Because Additive feats like Debilitating Bomb and Sticky Bomb both trigger when you use Quick Alchemy, you can use them to modify your bomb before you make it a Mega Bomb, allowing you to further improve your bomb.
- : Mutagens drawbacks are usually a minor annoyance, but some like Bestial Mutagen and Quicksilver Mutagen feature drawbacks which make you easier to kill.
- : If you run short on interesting Ancestry Feats, this is great. Consider Goblin so you can get Burn It! and Junk Tinker.
- : Always a trap. It's too easy to get enough Dexterity to fill out any armor your in, and there's no way to improve your proficiency beyond Trained so your upgraded armor will fall behind in a few levels.
- : Alchemists have low Will saves and poor Perception, and this is a great way to address that. Unfortunately, you can't take this twice.
- : Mutagenists either spend their time in melee trying to survive their 8+ hit points or fight at range trying to survive the hit point loss form Quicksilver mutagens. In either case, any Mutagenist needs as many hit points as they can get. Even with good Constitution, Toughness is still a good option.
- : If Bestial Mutagen doesn't look like a good option, any alchemist except the Bomber may want a better weapon option than a crossbow. Many races offer racial access to interesting weapons, but if yours doesn't Weapon Proficiency is a good way to get access to bows.
- : A handful of races have several excellent 1st-level Ancestry Feats, and at this level you may not have a lot of good General Feat options. If you're a Human, you can use this to get an Ancestry feat, then take General Training later to get a General Feat instead of an Ancestry Feat when you qualify for more feats.
- : Your best bet for long-range combat. Bombs are great, but their range is only 20 ft. (30 ft. or 60 ft. once you get some feats), so using a crossbow is a great way to remain effective at extended range.
- : Probably your go-to melee weapon unless your using Bestial Mutagen.
- : Doesn't take up a hand.
If your Ancestry feats give you access to other weapon options, look for options which work similarly to the options above. A regular bow may work better than a crossbow because you can make more attacks with it in a single turn, and something like a filcher's fork can be a great option for Mutagenists.
Wear the heaviest light armor you can manage without the check penalty. Of course, the check penalty for light armor is never worse than -1, so you may be fine with 8 Strength in a Chain Shirt. You're never going to get more than a total of +5 between your armor's base bonus and your Dexterity, so there's very little variance between armor options, and you're unlikely to exceed a +5 Dexterity modifier so dropping light armor likely isn't going to be worth the effort..
Other Magic Items
- : An inexpensive way to increase the amount of stuff you can carry. Alchemists tend to carry a lot of stuff around, and even though your alchemical items are only Light Bulk, they still add up over time as you gain the ability to craft ever-growing piles of items for free each day.
- : Rage is potentially useful for the Mutagenist, but that's the only interesting thing you can get.
- : Charisma-based
- : You get heavy armor proficiency from the base feat, but that proficiency never improves so with a trivial amount of Dexterity your AC in light armor will be higher than in heavy armor. You can take Diverse Armor Expert at 14th level, but that's two feats to get a total of +1 to AC (assuming that you're in heavy armor), and at 19th level your light armor will exceed the AC from heavy armor.
- : Wisdom-based spellcasting is the big draw.
- : Wisdom-base spellcasting. Wild Shape is tempting, but it's a Polymorph effect so you can't combine it with Mutagens.
- : Access to martial weapons is nice for anyone except Bombers, and you can take Diverse Weapon Expert to increase the proficiency to Expertise, which will match the best proficiency the Alchemist normally gets with any weapon. Mutagenists will enjoy the Fighter's various melee options, including great options like Opportunist and Snagging Strike.
- : Powerful Fists is a great replacement for Bestial Mutagen, and options like Crane Stance can make a Mutagenist much more effective in melee. Flurry of Blows is a great way to get an extra attack every turn, and since Bestial Mutagen and Crane Stance both add the Agile property to one of your unarmed strike options, either option will help mitigate the multiple attack penalty.
- : Hunt Prey is neat, but you don't get Hunter's Edge. The best thing you can get from the Ranger is Quick Draw, which allows you to draw and throw a bomb with a single action. Multiclassing into ranger also adds Snares as a possible option to double-down on crafting.
- : The base dedication feat is already really good. Suprise attack, Trained in two new skills, and a Skill Feat is a lot for one feat. Sneak Attacker is tempting, but 1d4 or 1d6 damage per attack simply isn't enough extra damage to justify the feat, so the only major reasons to take this are for Poison Weapon and Quick Draw. If you're going for a poisoner build, you definitely want to multiclass into Rogue. If you want to spam bombs, Quick Draw is great but you can also get it from the Ranger if that's more to your liking.
- : Charisma-based casting.
- : Intelligence-based casting is agreat addition to the Alchemists capabilities, especially for non-Bombers who lack quality long-range combat options. If you go beyond the base devotion feat, leveled spells offer you a wide selection of powerful utility options which you otherwise couldn't address with alchemical items alone.